than how skin looks.
It changes how it functions.
Menopause changes more
OUR SCIENCE
THE SCIENCE OF CHANGING SKIN
As estrogen declines, skin can lose moisture. lipids, collagen and resilience.
The fixx ritual is formulated around those changes.
Less
moisture
HOW HORMONAL CHANGES AFFECT SKIN
When estrogen changes, skin changes.
Estrogen helps influence hydration, collagen, elasticity and the skin barrier.
As levels decline through perimenopause and menopause skin can become drier, thinner, less resilient, and more sensitive.
Fewer
Barrier Lipids
Reduced
Structural support
01
PREPARE
Centle Cleanse
A three-step response
Formulated for what skin needs in this chapter
needs in this chapter
02
SUPPORT
Firmness, Resilience
03
SEAL
Structure , Barrier
Each formula has a distinct function, working synergistically to support
skin through menopause and beyond.
The formulation science
Advanced technologies.Selected for specific changes
We use clinically studied, high performance ingredient technologies to address what changing skin needs next.
Hyacare + Hyacare 50
Hydration
Help skin hold on to moisture
Two hyraluronic acid technologies selected
to attract and hold water in and on the skin's surface and help improve moisture retention,
Barrier Support
Replenish what changing skin can lose
A skin-lipid technology containing ceramides and other barrier compatible lipids, selected
to build and support the skin barrier and help reduce moisture loss.
Skinmimics Pro MB
Matryxyl 3000 · Progelene FF · Argireline . MDI CompleX · Snow algae powder
Firmness . Resilience
Support skin structure
Peptides and biotechnologies selected
to support the appearance of firmness,
elasticity, texture and resilience.
Designed to work together
Three steps. Designed for the skin you're in now.
PREPARE, SUPPORT and SEAL work in sequence to cleanse, hydrate, replenish and protect. Together, they form a barrier-first ritual designed specifically for changing skin.
Informed skin science
Research that guides our formulas
Our formulation approach is informed by research into the effects of hormonal change on skin and by published efficacy and safety data for the biotechnology that we use.
Reus TL, Brohem CA, Schuck DC, Lorencini M.
Revisiting the effects of menopause on the skin: Functional changes, clinical studies, in vitro models and therapeutic alternatives.
Mechanisms of Ageing and Development. 2020;185:111193.
Supports changes in skin collagen, water content, elasticity and thickness associated with menopause.
Kendall AC, Pilkington SM, Wray JR, et al.
Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy.
Scientific Reports. 2022;12:21715.
Supports menopause-related changes in ceramides and the skin barrier.
Calleja-Agius J, Brincat M.
The effect of menopause on the skin and other connective tissues. Gynecological Endocrinology. 2012;28(4):273–277.
Reviews the relationship between estrogen deficiency, collagen loss, skin thickness, elasticity and dryness.
Estrogen and skin: An overview.
American Journal of Clinical Dermatology. 2001. Reviews estrogen's role in skin collagen, moisture, hyaluronic acid and stratum-corneum barrier function.
